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KMID : 0438219790160030459
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Korea University Medical Journal
1979 Volume.16 No. 3 p.459 ~ p.470
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Chemotherapeutic Effect of Praziquantel (Embay 8440) in the Treatment of Clonorchiasis sinensis
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林漢鍾/Rim, Han-Jong
柳光司/Yoo, Kwang-Sa
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Abstract
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A total of 162 patients with proven Clonorchis sinensis infection were treated by 8 different dosages with praziquantel at a single dose and 2 or 3 divided doses on a single or two days. A single dose of 40 mg/kg bwt and 50 mg/kg bwt of praziquantel were given to 28 and 15 patients respectively and each-15 patients were treated with a single dose of 20
- mg/kg bwt and 30 mg/kg bwt for 2 days. Follow-up examinations were carried out at about 30 and 60 days after treatment. Two months after therapy, the results were shown 82.6 to 99.1% in the egg reduction rates but only 6.7% (in dosage group of 20 mg/kgx2 days) to 33.3% (in dosage group of 50 mg/kgx 1 day) in cure rates. On the other hand, two doses of 25 mg/kg bwt (50 mg/kg bwt) and 3 doses of 25 mg/kg (75 mg/kg bwt) of praziquantel with the interval of 6 hours on one or two days were given to the other patients. The dosage of 2X25 mg/kgx 1 day and 2X25 mg/kgx 2 days were given to 15 and 24 patients respectively. The high egg reduction rates of 97.4% and 99.9% were shown in the follow-up examinations, however 46. 7% and 75.0% of cure rates were obtained. Considerably high egg reduction rate (99.7%) and cure rate (85. 7%) were obtained in 35 patients received 3 x 25 mg/kg bwt in a single day. However in 15 patients received 3 x 25 mg/kg bwt for two days complete cure was obtained at the follow-up examinations.
In case eggs were found at the first or second follow-up examination, patients were treated again with the same dosage of praziquantel and another follow-up period of 60 days was required. Six of 24 patients received 2 x 25 mg/kg x 2 days and 5 of 35 patients received
3 x 25 mg/kg x 1 day treated again with the same dosage of praziquantel and all were completely cured. After a single dose of 40 mg/kgx I day, only 7 of 28 patients were cured at 30 and 60 days after therapy, and 21 patients received for another time 40 mg/kg once on a single day and 7 of these 21 patients (33. 3%) were cured. The remaining 14 patients showed egg reduction rates of over 90%. Therefore 50.0,,o of cure rate was obtained after -the 2nd medication. Eight of 15 cases received 2x25 mg/kg xI day were treated again with the same dosage, and only 4 cases were cured. In the final result, 73.3% of cure rate with 99.061 of egg reduction rate was shown at 60 days follow-up examination after the second medication.
The assessment of tolerance recorded only a few side effects, such as headache, dizziness and nausea etc. Extended hematological and biochemical tests showed no abnormal findings after thereapy which might be due to the medication.
It was evidently shown that the human clonorchiasis could be successfully treated with a few doses of praziquantel without any serious side effects. Therefore praziquantel is the most promising drug for the treatment against Clonorclus sinensis infection.
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